Tildipirosin
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Tildipirosin
Tildipirosin waa nooc cusub oo ka mid ah 16-xubnood oo semi-synthetic ah oo ka kooban antibiyootiga macrolide ee xayawaanka, kaas oo ka soo jeeda tylosin.
Falka dawooyinka
Saamaynta bakteeriyada Tildipirosin waxay la mid tahay tan tylosin, waxayna leedahay saameyn xooggan oo ka hortag ah bakteeriyada Gram-positive iyo bakteeriyada Gram-negative.Habka bakteeriyada Tildipirosin waxay la mid tahay tan macrolides.Waxay ku dari kartaa qaybta 50S ee ribosome ee bakteeriyada xasaasiga ah si ay u joojiso isku-dhafka silsiladaha peptide riboprotein, taas oo saameynaysa isku-dhafka borotiinnada bakteeriyada.Isdhexgalka labada qaybood ee piperidine ee gaarka ah ee Tildipirosin waxay kala soocaan habka ficilka daawadan laga bilaabo tylosin iyo tilmicosin, halkaas oo 20-piperidine lagu hagayo lumen si loo farageliyo koritaanka peptides-ka dhallaanka ah.
Sababtoo ah tediroxine waxay leedahay 3 kooxood oo amino oo aasaasi ah, waxay samayn kartaa foomamka dallacaadda ee kala duwan ee xaaladaha pH ee kala duwan.Qadarka kharashka ayaa ah arrin muhiim ah oo lagu burburiyo milanka xuubka bakteeriyada oo uu galo xuubka dibedda ee bakteeriyada Gram-negative, sidaas darteed waxqabadka bakteeriyada Tildipirosin ee vitro waxaa si weyn u saameeya pH.Marka la eego xaaladaha acidic, kooxda amino-ku waa protoned, taasoo keentay hoos u dhac ku yimaada waxqabadka bakteeriyada tediroxine, halka xaaladaha alkaline, ay leedahay firfircooni bakteeriyada xooggan.
Macrolides waxay xakameysaa dheecaanka cytokines proinflammatory, dhaqdhaqaaqa fosfolipase, iyo sii deynta leukotriene, waxayna leeyihiin saameyn liddi ku ah bararka macrophages iyo neutrophils.Tediroxine waxay yaraynaysaa dhexdhexaadiyeyaasha bararka ee la soo saaro inta lagu jiro jawaabaha bararka ama walaaca qaarkood.
Bakteeriyada bakteeriyada
Tildipirosin waxay wax ku ool u tahay bakteeriyada pathogenic ee sababa cudurrada neef-mareenka ee doofaarka iyo lo'da (sida Pasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. iwm) Bakteeriyada bakteeriyada tilmicosin waxay ahayd 2-32 jeer ka badan tilmi , iyo waxqabadka bakteeriyada lidka ku ah mindhicirka Escherichia coli ayaa ka fiicnaa tilmicosin iyo tylosin.Waxa kale oo ay xasaasi u tahay qaar ka mid ah noocyada mycoplasma, spirochetes, brucella, iwm. Daraasaduhu waxay muujiyeen in tediroxine ay saameyn xooggan ku leedahay bakteeriyada Haemophilus parasuis iyo Bordetella bronchiseptica marka loo eego florfenicol, laakiin saameynta bacteriostatic daciifka ah ee Actinobacillus pleuropneumoniae iyo Pasteurella mulze.Tildipirosin waxay bakteeriya u tahay bakteeriyada qaarkood (sida Haemophilus parasuis iyo Actinobacillus pleuropneumoniae), halka ay inta badan bakteeriyada u tahay bakteeriyada qaar (sida Pasteurella multocida).Bakteeriyada mindhicirka, hoos u dhaca qiimaha pH (laga bilaabo 7.3 ilaa 6.7), MIC ee Tildipirosin ayaa kordhay, tusaale ahaan, MIC of Tildipirosin ka dhanka ah Salmonella Enteritidis iyo Escherichia coli waxay ka kordhin kartaa 2 ~ 8ug / m ilaa 64 ~ 256ug / mL .Sidaa darteed, saameynta pH ee isbeddelka vivo waa in la tixgeliyo marka la samaynayo tijaabada bakteeriyada Tildipirosin ee in vivo.Intaa waxaa dheer, MIC ee Tildipirosin ee ka soo horjeeda noocyada caadiga ah ee Pasteurella multocida waxay ahayd 0.5ug / mL ee serum, taas oo 0.25 jeer ka hooseysa tan in vitro, taas oo laga yaabo inay la xiriirto saameynta serum.
Enterococcus-Streptococcus oo ku jira lo'da caanaha ayaa aad ugu adkeysanaya tediroxine.Tildipirosin waa dareen la'aan Pasteurella multocida iyo Mannheimia hemolyticus oo sidda hiddo-wadaha mutant.Sidoo kale, noocyada hidde beddelka ee M. bovis ayaa u adkaysta antibiyootiga macrolide oo ay ku jiraan Tildipirosin.Noocyada qaarkood ee Haemophilus parasuis ayaa sidoo kale la ogaaday inay si dabiici ah u adkaysanayaan tediroxine.Mycoplasma bovis waxay si dhakhso ah u yeelan kartaa caabbinta Tildipirosin, laakiin korriinka gaabiska ah ee Mycoplasma awgeed, baaritaanka u nuglaanta maandooriyaha ee vitro waxay dib u dhigi kartaa daaweynta.Daraasaduhu waxay muujiyeen in domain II (nucleotide 748) iyo domain V (Isbeddellada nucleotides 2059 iyo 2060) ay la xiriiraan kororka caabbinta macrolides.Sidaa darteed, u nuglaanshaha M. bovis ee dawooyinka macrolide si degdeg ah ayaa loo heli karaa baaritaanka molecular ee isbeddelkan.
Nuxurka
≥ 98%
Tilmaamid
Heerka shirkadda
Hebei Veyong Pharmaceutical Co., Ltd, waxaa la aasaasay 2002, oo ku yaala Shijiazhuang City, Gobolka Hebei, Shiinaha, ee ku xiga caasimadda Beijing.Iyadu waa shirkad weyn oo GMP-shahaad ka siisay dawada xoolaha, oo leh R&D, wax soo saarka iyo iibinta API-yada caafimaadka xoolaha, diyaarinta, quudinta premixed iyo quudinta lagu daro.Iyada oo ah Xarunta Farsamada Gobolka, Veyong waxay dejisay nidaam R&D cusub oo loogu talagalay daawaynta cusub ee caafimaadka xoolaha, waana tan qaran ahaan loo yaqaan hal-abuurnimada tignoolajiyada ganacsiga xoolaha, waxaa jira 65 xirfadlayaal farsamo.Veyong waxa uu leeyahay laba saldhig wax soo saarka: Shijiazhuang iyo Ordos, kuwaas oo saldhigga Shijiazhuang daboolayaa meel of 78,706 m2, oo leh 13 alaabta API oo ay ku jiraan Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, iyo 11 khadadka wax soo saarka diyaarinta oo ay ku jiraan duritaanka, xal afka, , premix, bolus, sunta cayayaanka iyo jeermiska dila, iwm.Veyong waxay bixisaa API-yo, in ka badan 100-u-diyaarin summada leh, iyo adeegga OEM & ODM.
Veyong waxa ay muhiimad weyn siisaa maaraynta nidaamka EHS(Deegaanka, Caafimaadka & Badbaadada), waxa uuna helay shahaadooyinka ISO14001 iyo OHSAS18001.Veyong waxa lagu taxay istaraatiijiyada ganacsi ee soo koraya ee warshadaha ee Gobolka Hebei waxana ay xaqiijin kartaa sahayda joogtada ah ee alaabta.
Veyong wuxuu aasaasay nidaamka maaraynta tayada dhamaystiran, wuxuu helay shahaadada ISO9001, shahaadada Shiinaha GMP, shahaadada Australia APVMA GMP, shahaadada Itoobiya GMP, shahaadada Ivermectin CEP, waxayna dhaaftay baadhista US FDA.Veyong waxay leedahay koox xirfadlayaal ah oo diiwaan gelinta, iibinta iyo adeegga farsamada, shirkadeena waxay ka heshay ku tiirsanaanta iyo taageerada macaamiisheeda tiro badan oo tayo sare leh oo tayo sare leh, iibka hore iyo adeegga iibka ka dib, maamulka culus iyo sayniska.Veyong waxa ay wada shaqayn muddo dheer ah la samaysay shirkado badan oo caalami ah oo loo yaqaan farmashiyaha xoolaha oo wata badeecadaha loo dhoofiyo Yurub, Koonfurta Ameerika, Bariga Dhexe, Afrika, Aasiya, iwm in ka badan 60 waddan iyo gobollo.
